Antihypertensive agents reduce high blood pressure. These studies confirm Moringa oleifera's hypotensive activity.
Isolation and structure elucidation of new nitrile and mustard oil glycosides from Moringa oleifera and their effect on blood pressure. Journal of Natural Products, 57(9), 1256-1261. Faizi, S., Siddiqui, B. S., Saleem, R., Siddiqui, S., Aftab, K., & Gilani, A. U. H. (1994).
This study shows that Moringa oleifera leaves can reduce blood pressure. Their hypotensive activity is derived from isothiocyanates and thiocarbamate glycosides .
Fully acetylated carbamate and hypotensive thiocarbamate glycosides from Moringa oleifera. Phytochemistry, 38(4), 957-963. Faizi, S., Siddiqui, B. S., Saleem, R., Siddiqui, S., & Aftab, K. (1995).
This study shows that six new and three synthetically known glycosides can be isolated from the leaves of Moringa oleifera. Most of these compounds are very rare in nature. Thiocarbamates showed strong hypotensive activity.
PPARδ, a Potential Therapeutic Target for Heart Disease. Nuclear Receptor Research, 5. Yang, Q., & Long, Q. (2018).
Pharmacological studies show that Moringa oleifera seeds protect the heart from TAC-induced pressure overload or hypertension from the development of hypertrophy via enhancing cardiac PPARδ expression.
Hypotensive constituents from the pods of Moringa oleifera. Planta medica, 64(03), 225-228. Faizi, S., Siddiqui, B. S., Saleem, R., Aftab, K., & Shaheen, F. (1998).
This study investigates the hypotensive activity of the ethanolic and aqueous extracts of Moringa oleifera whole pods and their parts, namely, coat, pulp, and seed. The activity of the ethanolic extract of both the pods and the seeds was equivalent. Thiocarbamate and isothiocyanate glycosides are the hypotensive principles of the pods and leaves of Moringa oleifera.
Cardiac protective effects of Moringa oleifera seeds in spontaneous hypertensive rats. American journal of hypertension, 29(7), 873-881. Randriamboavonjy, J. I., Loirand, G., Vaillant, N., Lauzier, B., Derbré, S., Michalet, S., ... & Tesse, A. (2016).
This study shows that the administration of Moringa Oleifera seed powder has a beneficial effect on the cardiac structure and function in hypertensive rats associated with an upregulation of PPAR-α and δ signaling. This study thus provides scientific rational support for the empirical use of Moringa Oleifera in the traditional Malagasy medicine against cardiac diseases associated with blood pressure overload.
Pharmacological studies on hypotensive and spasmolytic activities of pure compounds from Moringa oleifera. Phytotherapy research, 8(2), 87-91.ISO 690 Gilani, A. H., Aftab, K., Suria, A., Siddiqui, S., Salem, R., Siddiqui, B. S., & Faizi, S. (1994).
This study shows that ethanolic extracts of Moringa oleifera leaves resulted in the isolation of four pure compounds, niazinin A (1), niazinin B (2), niazimicin (3) and niaziminin A + B (4 + 5). Intravenous administration of either one of the compounds (1–10 mg/kg) produced hypotensive and bradycardiac effects. The data indicates that spasmolytic activity exhibited by the constituents of the plant provides a scientific basis for the traditional uses of the plant in gastrointestinal motility disorders.
Investigating of Moringa Oleifera Role on Gut Microbiota Composition and Inflammation Associated with Obesity Following High Fat Diet Feeding. Open access Macedonian journal of medical sciences, 6(8), 1359. Elabd, E. M. Y., Morsy, S. M., & Elmalt, H. A. (2018).
Findings suggest that Moringa oliefera aqueous leaf extract contribute towards the pathophysiological regulation of weight gain and inflammation associated with high-fat-induced-obesity through gut bacteria modulation.
Pharmacological studies of thiocarbamate glycosides isolated from Moringa oleifera. J. Sci. Soc. Thailand, 23, 335. Jansakul, C., Wun-Noi, A., Croft, K., & Byrne, L. (1997)
Methanolic extracts of dried pods and seeds of Moringa Oleifera resulted in the isolation of a mixture of thiocarbamate glycosides of niazimicin and niaziminin; both compounds known to reduce blood pressure and heart rates.