Medicinal plants such as Moringa Oleifera provide inexhaustible sources of anticancer drugs in terms of both variety and mechanism of action. Induction of apoptosis (programmed cell-death) is the key to plant's anticancer properties.
Niaziminin, a thiocarbamate from the leaves of Moringa oleifera, holds a strict structural requirement for inhibition of tumor-promoter-induced Epstein-Barr virus activation. Planta Medica, 64(04), 319-323. Murakami, A., Kitazono, Y., Jiwajinda, S., Koshimizu, K., & Ohigashi, H. (1998).
This study shows that powerful tumor inhibiting compounds can be extracted from Moringa Oleifera leaves. In conclusion, three known thiocarbamate (TC)- and isothiocyanate (ITC)-related compounds have been isolated from the leaves of Moringa oleifera as inhibitors of tumor promoters.
An antitumor promoter from Moringa oleifera Lam. Mutation Research/Genetic Toxicology and Environmental Mutagenesis, 440(2), 181-188. Guevara, A. P., Vargas, C., Sakurai, H., Fujiwara, Y., Hashimoto, K., Maoka, T., ... & Nishino, H. (1999).
This study examines bioactive compounds with anti-tumor potential present in the seeds of Moringa oleifera. The results show that potent chemo-preventive agents are present in Moringa seeds.
Chemomodulatory effect of Moringa oleifera, Lam, on hepatic carcinogen metabolising enzymes, antioxidant parameters and skin papillomagenesis in mice. Asian Pacific Journal of Cancer Prevention, 4(2), 131-140. Bharali, R., Tabassum, J., & Azad, M. R. H. (2003).
This study shows the potential chemopreventive potential of Moringa oleifera's pod extracts against chemical carcinogenesis.
Medicinal properties of Moringa oleifera: An overview of promising healer. Journal of Medicinal Plants Research, 6(27), 4368-4374. Farooq, F., Rai, M., Tiwari, A., Khan, A. A., & Farooq, S. (2012).
This study shows that every part of the Moringa tree is valuable. Further research on this charismatic healer may lead to the development of novel agents for various diseases. This study provides a brief overview about medicinal potential of Moringa and its future as a component of modern medicinal system.
Antiproliferation and induction of apoptosis by Moringa oleifera leaf extract on human cancer cells. Food and Chemical Toxicology, 49(6), 1270-1275. Sreelatha, S., Jeyachitra, A., & Padma, P. R. (2011).
This study was designed to determine the antiproliferative and apoptotic events of Moringa oleifera leaf extract. The findings suggest that the leaf extracts from M. oleifera have strong antiproliferation and potent induction of apoptosis. They indicate that M. oleifera leaf extracts have potential for cancer chemoprevention and can be claimed as therapeutic targets for cancer.